PCOS: Hormonal and Metabolic Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women, characterized by androgen excess, ovulatory dysfunction, and metabolic disturbances including insulin resistance.
PFAS and Androgen Pathways
PFAS compounds alter androgen biosynthesis by affecting steroidogenic enzymes including CYP17A1. Women with high PFAS exposure show elevated free testosterone and dehydroepiandrosterone sulfate (DHEAS) levels in some cohort studies.
Insulin Resistance Connection
PFAS impair insulin signaling by disrupting peroxisome proliferator-activated receptor (PPAR) function. Combined with androgen excess, this creates a metabolic syndrome profile consistent with severe PCOS phenotype.
Management and Monitoring
Clinicians managing PCOS should inquire about PFAS exposures including drinking water source and dietary habits. PFAS-aware lifestyle modifications may complement standard hormonal and metabolic therapies.